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21'
This goal: 0–0 → 0–1 · opening goal

Away side 1. FSV Mainz 05 struck first at the Rhein-Neckar-Arena on 11 September 2021, when Jonathan Burkardt scored in the 21st minute to make it 0-1 against TSG Hoffenheim. The first-half opener set the course for the Bundesliga Matchday 4 fixture. Mainz never surrendered the lead, and Burkardt's goal stood as the winner in a 0-2 victory.

Competition
Bundesliga Matchday 4
Date
11 September 2021
Stadium
Rhein-Neckar-Arena
Final score
TSG Hoffenheim 0-2 1. FSV Mainz 05
Attendance
8,427