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21'
Inter 1 – 0 Sampdoria
This goal: 0–0 → 1–0 · opening goal

Inter's home meeting with Sampdoria at San Siro on matchday 12 of Serie A was opened up in the 21st minute, when Stefan de Vrij broke the deadlock to make it 1-0. It was the first goal of the afternoon and set the tone for what followed. Inter never surrendered that advantage, so de Vrij's strike ultimately stood as the winning goal.

Competition
Serie A Matchday 12
Date
29 October 2022
Stadium
San Siro
Final score
Inter 3-0 Sampdoria
Attendance
73,311